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Obesity Reviews, 23(5), e13492

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Inhibition of glycolysis decreases the expression of IL-6, IL-8, IL-1 and COX-2 induced by bTNF- in bFLS We have previously reported that bTNF- increases the expression of glycolytic genes such as GLUT1 and PDK1 24

Its capacity to accelerate antidepressant onset, improve cognition, enhance sleep architecture, and reduce biomarkers of neuronal injury positions it as a neuroprotective adjunct rather than a primary antidepressant monotherapy